Examples cells is the answer. At first, it

Examples of New Approach of Drug
Delivery System

1.     
Printing Of
Small Molecular Medicines From The Vapor Phase

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The growing
need to develop efficient methods for early stage drug discovery, continuous
manufacturing of drug delivery vehicles, and ultra-precise dosing of high
potency drugs. The manufacturer of film form medicine like the dispersion of
API particles in a matrix of polymer by doing the mixing, spraying, dipping and
folloed by extrusion or casting (18). The approaches were suffer from limited
dispersion of particle, stability, and loading of drug, in particular if
working with nanoparticles(14). To overcome the problem above, we using a
process which originally developed to achieve the continuity, free of solvent,
big scale, high-troughput, yet ultra-precise printing of small-molecular
organic semiconductor or what we called as organic vapor jet printing (OVJP)
(22) as the results we got the small pharmaceutical ingredients molecular which
is have the nanocrystalline morphology. The printed films show dissolution
kinetics substantially enhanced compared with it’s powder form.

2.     
Mesoporous
silica nanoparticles as controlled release drug delivery and gene transfection
carriers

At
some cases, for example the chemotheraphy for cancer, the current treatment
method mainly rely on the use of cytotoxic drugs that only have limited
effectiveness and adverse side effect. Many studies have indicated these
problems could be caused by the lack of target specificity in the formula of
antitumor drugs. To overcome this problems a pursuit to design a target
specific drug delivery system that can transport an effective dosage of drug
molecules to targeted tissues and cells is the answer. At first, it looks
nearly impossible to found the material that have high fondness for adsorbing
certain drug molecules, yet willingly to release the same compound upon
reaching the designated tissues or cells. Recently some of “smart” drug
delivery system which is biodegradable compounds such as  liposomes, dendrimers, and polymeric
nanoparticles that can control the release of pharmaceutical drugs solution of
water upon the degradation of the carrier trigerred by various factor for
example the pH or under physiological conditions. While some drug delivery
system have been following this approach, it is still a challenge to eliminate
the premature release of drug in these structurally unstable compounds. In
another hands some good progress shown promise on the uses of mesoporous silica
nanoparticles as intracellular controlled release drug delivery agents. The
mechanism which transformed non-functionalized MSN into stimuli-responsive drug
delivery agents have been established, although further improvements are
expected in terms of increasing the inventory of gatekeepers and controlled
release mechanisms. With this great potential, in the future application it is
possible that some functionalized MSN perform specific tasks inside of
cells.(2)

3.     
Gold
nanoparticles in delivery applications

Gold
nanoparticles (GNPs) have recently emerged as an attractive candidate as an
drug delivery agents because it provide non-toxic carriers for drug and gene
delivery application. The other advantage is their ease of synthesis, the
monodisperse of gold nanoparticles can be formed with core sizes ranging from 1
nm to 150 nm and also the photophysical properties could trigger drug release
at certain places.

Figure 1. Various
application of gold nanoparticles in theraphy

In
biomolecules, GNPs have shown the success as drug delivery materials for
DNA/RNA, peptides and proteins. It is been known that viruses could provide a
vehicle for gene theraphy and had been shown highly efficient. (52) The
effective delivery vehicles need to provide efficient protection of nucleic
acid from degradation by nucleases, efficient cell entry, and release of the
nucleic acid in functional form in the nucleus (55). GNPs can be made a small particle
to provide a high surface to volume ratio, maximizing the carrier ratio. There
is also a photothermal effect of gold nanoparticles in theraphy. El Sayed et
al. have recently reported about potential use of GNPs in photothermal
destruction of tumors (68). Citrate-stabilized GNPs (core d=30 nm) were coated
with anti-EGFR (epidermal growth factor receptor) to target HSC3 cancer cells
(human oral squamous cell carcinoma). The use of GNPs enhanced the efficacy of
photothermal therapy by 20 times. The GNPs have been showing its promising
results as an drug delivery agents. Mostly because of it’s combination of low
inherent toxicity, high surface area and tunable stability provides them with
unique attributes that should enable new delivery strategies.