Multi-compartment of the medication the patient is receiving

Multi-compartmentcompliance aids (MCA’s) are being increasingly used in both primary andsecondary care settings to assist patients with medicine compliance, in both asafe and effective manner. The devices not only help patients to remember totake their medication, but also acts as a visual prompt for carers enablingthem to see whether their patients have had their appropriate doses1.

  Additionally, MCA’s are anindispensable tool in polypharmacy2, with the potential to reducewastage3. MCA’sare particularly useful for the elderly population and the visually impaired whomay have difficulty managing complex drug regimens and are looking to promoteindependence with their medicines4. The packaging allows days of theweek to be incorporated, allowing patients to follow a specific drug regime,organised by dosing intervals. Hence, minimising errors associated withadministrating incorrect doses at incorrect times. The pharmacist may arrangethe aids, placing different medications in the same compartment; allowing themto keep track of the medication the patient is receiving every day, ensuring itis taken at the desired time.

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However,MCA’s pose a concern regarding product stability as medicines are removed fromtheir manufacturers original packaging, and has even prompted pharmacists toestablish a database on product stability5. Repackagingmay even be warranted as unlicensed use of the product and may invalidate the statedexpiry date2. Theoriginal packaging has been designed with the appropriate pharmacopoeial andquality standards in mind1, and dosage forms are required to meetBritish Pharmacopoeial requirements including content uniformity. Other factorswhich are considered during drug design are the effects of humidity,temperature and oxygen.

MCA’s cannot guarantee the same levelof protection, and the pharmacist must use their clinical judgment to prepareone or not. The compliance aids are not air tight and provide less moistureprotection than original packaging. This may lead to chemical and physicaldeterioration, reducing efficacy and compromising patient safety.  Often systems are re-used without cleaning posingthe risk of chemical and microbiological contamination.

Also,certain formulations cannot be repackaged (e.g. those which are refrigerated,dispersible tablets, hygroscopic preparations and solid dose cytotoxic medicationsincluding methotrexate).

The Royal Pharmaceutical Society also includes medicines with variable dosing anda narrow therapeutic index such as warfarin6.