Problem speak or understand speaking, lack of concentration,

Problem Statement: Creutzfeldt Jakob Disease (CJD) is a genetic/brain disorder that causes personality changes, anxiety, depression and memory loss.  With this disease, many people may lapse into a coma within a few months. It’s an extremely rare disease, CJD doesn’t have a cure but it does have treatments.

This disorder can lead to dementia and death.  History of CJD: CJD was described in the 1900’s as a small outbreak in the United Kingdom. People thought it was because eating a beef infected prion protein. There are fewer than 1,000 US cases each year. The symptoms of CJD include amnesia, mental confusion, dementia, delusion, distention, inability to speak or understand speaking, lack of concentration, rhythmic muscle concentration, slow movements, muscles spasms, problems with coordination, and overactive reflexes.

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When this disease your mood can change into anxiety or apathy. Some common things that can occur when you have CJD are blurred vision, difficulty speaking, insomnia, personality change, or rapid involuntary eye movement. People that develop this disease can get it around the age of 60 or they can genetically develop it. When people first have this disease, they may experience filing memory, behavior changes, lack of coordination and visual disturbances. Treatments and cures:  There is no cure for Creutzfeldt Jakob Disease, but there are treatments. The treatments are just to relieve pain, the treatments are clonazepam and sodium valproate and they may help relieve myoclonus or irregular movement.

CJD is genetically inherited. There are some cases that emerge from a mutation or modified gene that controls the formation of the normal prion protein. If the prion protein gene is adjusted in a person’s sperm or egg cell the CJD can be transmitted to the persons’ offspring. There are 2 Universities that research Creutzfeldt Jakob Disease those Universities are Harvard University and The University of Edinburgh.  The University of Edinburgh says that there are 3 major categories of CJD. The first is sporadic CJD which a person can get even though they don’t have any risk factors for getting this disease.

The second disease is hereditary which a person can get when a family has a history of this disease and test positive for this genetic mutation to be passed down. The final category is acquired CJD which means this disease is transmitted by exposure to the brain or nervous system tissues usually through certain medical procedures.  There is no proven evidence that CJD is contagious. CJD also belongs to a family of animal and humans known as transmissible spongiform encephalopathies. Animals can suffer from Creutzfeldt Jakob Disease such as cows, sheep, goats, elk, deer, and exotic zoo animals.  The science behind CJD: The scientific explanation behind CJD is that it’s caused by a type of protein called a prion. A prion protein contains in both a normal form, which is harmless that is found in the body’s cells and in an infectious form which can cause CJD. Both of the harmless and infectious forms contain the same sequence of amino acids.

The infectious form of the prion protein takes a different shape than the normal prion protein. Sporadic CJD can occur when a person’s normal prions spontaneously alter into the infectious prion protein. After the prions change in other cells chain reactions happen.

Once these prions appear abnormal prion proteins aggregate, or cluster together. Investigators think these proteins may lead to the neuron loss and other brain damages seen in CJD.  Conclusion: In conclusion, Creutzfeldt Jakob Disease is a very rare and deadly disorder that causes many fatal symptoms. 90 percent of people that have this disorder don’t survive more than a year, there isn’t much research on CJD and there is no cure for it.